Assessment of threatened status, phytochemical composition and biological properties of three Aconitum species from Kashmir Himalaya - India

Genus Aconitum (Ranunculaceae) is represented by 6–8 species from Kashmir Himalaya. Traditionally are used to treat a wide array of diseases, but their ethnopharmacological validation and phytochemistry hitherto unreported The present study was undertaken bring insights into the traditional use distribution pattern three region. An ethnobotany-directed approach employed conservation status species. Their phytochemical profiles biological properties were screened under in vitro conditions. Folin–ciocalteu Aluminium chloride assays measure total phenolic flavonoid contents, respectively. Plant extracts evaluated for antioxidant, antimicrobial anti-inflammatory activities. Three species, viz. heterophyllum Wall. ex Royle, violaceum Jacquem. Stapf chasmanthum Stapf. Holmes showed dwindling significant variations contents. Antioxidant activity methanolic extract studied be comparatively higher (80.115%). DCM & good MIC value 0.125 mg/ml against Candida albicans Streptococus pyogenes, percent inhibition NLRP inflammasome found ethyl acetate (74.61%). revealed that constantly declining at least investigated habitats Himalaya hence need strategic planning. results also emphasized utility as an agent could manage various health problems.